Personnel who are supervising or performing drug manufacturing or control can be a potential source of microbiological contamination and a vector for other contaminants.

The main reasons for contamination from the personnel include:

• Lack of training
• Direct contact between the operator’s hands and starting materials, primary packaging materials and intermediate or bulk product
• Inadequate personnel cleanliness
• Access of unauthorized personnel into production, storage, and product control areas
• Inadequate gowning and personnel protective equipment
• Malpractices like eating food, drinking beverages, or using tobacco in the storage and processing areas.